访问到访问的血压变化与内在能力下降有关:来自MAPT研究的结果
Leonardo Bencivenga1, Mathilde Strumia2, Yves Rolland3
1Department of Translational Medical Sciences, University of Naples Federico II, Napoli, Italy; Gérontopôle de Toulouse, Institut du Vieillissement, CHU de Toulouse, France.
European journal of internal medicine
|March 18, 2024
概括
增加的血压变化 (BPV) 与老年人内在能力 (IC) 的下降有关. 这表明BPV可能是衰老的标志物和促进健康衰老的目标.
科学领域:
- 老年学是指老年学的学科.
- 心血管健康 心血管健康
- 衰老研究研究 衰老研究
背景情况:
- 随着年龄的增长,生理调节机制会下降,这可能会增加血压变化 (BPV).
- 内在能力 (IC) 是功能能力的衡量标准,被世界卫生组织提议作为健康衰老的标志物.
- 研究老年人BPV和IC下降之间的联系对于了解衰老过程至关重要.
研究的目的:
- 检查访问到访问的血压变化 (BPV) 和内在能力 (IC) 的下降之间的关联.
- 为了确定BPV是否是社区居住的老年人心血管平衡改变的指标.
- 探索BPV作为衰老的潜在临床标志物和健康衰老的可修改风险因素.
主要方法:
- 该研究包括来自MAPT研究的70岁以上的1407名社区居民参与者,在5年的随访期间进行了随访.
- 使用六个指标测量了系统性和透缩性BPV;在认知,心理,运动和活力领域评估了IC.
- 分析了总的ICZ分数和随着时间推移的域损伤的发生率.
主要成果:
- 较高的静脉血压 (SBPV) 与较差的整体IC Z-分数 (p < 0.01) 有显著的关联.
- 更高的透析血压 (DBPV) 也与较差的IC Z-分数 (p = 0.02) 有关.
- 较大的SBPV增加了发生IC损伤的风险 (HR=1.16,p=0.03),而DBPV没有显示出显著的关联.
结论:
- 增加的BPV与老年人的内在能力随着时间的推移而下降有关.
- 血压不稳定可能表明心血管恒温机制发生变化.
- BPV可以作为衰老的临床标志物和促进健康衰老的干预措施的目标.
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