癌症患者的COVID-19疫苗接种:第三剂接种一年后的免疫反应
Roberta Campagna1, Federica Dominelli2, Maria Antonella Zingaropoli2
1Department of Molecular Medicine Sapienza University of Rome, Viale dell'Università, 33, 000185 Rome, Italy.
Vaccine
|March 18, 2024
概括
癌症患者 (CPs) 对COVID-19疫苗的免疫反应减弱,即使在多剂量后. 补充剂注射和考虑癌症治疗对于提高疫苗在这个脆弱人群中的有效性至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 癌症患者 (CPs) 免疫力低下,增加他们患重症COVID-19的风险.
- 对于公共卫生战略来说,评估CPs中的疫苗免疫性至关重要.
研究的目的:
- 为了评估抗SARS-CoV-2疫苗在固体瘤CP的免疫反应,在第三剂后一年.
- 为了确定癌症治疗对疫苗免疫性的影响.
主要方法:
- 结合和中和抗体 (Ab) 标位通过化学发光免疫测试 (CLIA) 和斑块减少中和测试 (PRNT) 进行测量.
- 使用多参数流细胞计分析了T细胞反应.
- 在CP (3vs4剂量) 和健康捐赠者 (HDs) 之间,以及在CP与或没有之前的SARS-CoV-2感染之间,以及在免疫治疗和非免疫治疗组之间进行比较.
主要成果:
- 接种了三剂疫苗的CP比接种了四剂和HDs的CP有较低的Ab标位.
- 慢性病患者通常表现出较弱的细胞介导反应,单功能T细胞占主导地位.
- 在没有先前感染SARS-CoV-2的CP中观察到较低的Ab标位和T细胞反应.
- 与非免疫疗法CP相比,免疫疗法CP表现出更强的T细胞反应.
结论:
- 慢性病医生需要补充剂量才能达到与HD相比的保护水平.
- 癌症治疗方式影响疫苗免疫性,特别是T细胞反应.
- 考虑到先前的感染和治疗,个性化的疫苗接种策略对于CP很重要.
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