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对抗精神病药物的坚持评价:使用四种不同的剂量假设进行现实数据研究
Marina Fuente-Moreno1,2,3, Alexandra L Dima1,4, Maria Rubio-Valera1,4
1Health Technology Assessment in Primary Care and Mental Health (PRISMA) Research Group, Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain.
British journal of clinical pharmacology
|March 18, 2024
概括
在抗精神病药物处方中,剂量不一致是常见的. 虽然大多数策略都产生了类似的坚持估计,但选择最高剂量可能为抗精神病治疗坚持提供更准确的衡量标准.
科学领域:
- 药理学和药理学流行病学
- 精神病学药房实践 精神病学药房实践
- 药物坚持研究 药物坚持研究
背景情况:
- 坚持抗精神病治疗对于管理慢性精神健康状况至关重要.
- 处方数据通常含有剂量不一致,复杂的坚持评估.
- 了解这些不一致性对于准确的患者护理和治疗结果至关重要.
研究的目的:
- 评估抗精神病药物处方中剂量不一致的频率.
- 评估四种不同剂量假设策略对坚持估计的影响.
- 确定最准确的方法来估计抗精神病治疗的坚持.
主要方法:
- 在西班牙加泰罗尼亚进行了回顾性队列研究,将处方和发行数据 (2015-2019) 联系起来.
- 对至少有一种抗精神病药物处方的成年患者的分析.
- 他们比较了处理重叠处方的四种策略:最小剂量,最新剂量,最高剂量和所有剂量;依赖度以连续药物可用性来衡量.
主要成果:
- 在277324个处方中,超过76%的处方重叠,其中40%的处方说明不同.
- 平均坚持估计在各种策略中是相似的 (57-60%).
- 较高比例的患者实现了≥90%的遵守"所有剂量"以外的策略 (35%对28%).
结论:
- 存在重叠抗精神病药物处方的高患病率.
- 选择的剂量策略对整体坚持估计的影响有限.
- 在重叠期间选择最高剂量可以提供更准确的抗精神病治疗的坚持估计,考虑到处方做法.
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