移动健康技术检测到的转向变化在异常REM睡眠行为障碍中
Cinzia Zatti1,2,3, Andrea Pilotto4,5,6, Clint Hansen7
1Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
NPJ Parkinson's disease
|March 19, 2024
概括
异常REM睡眠行为障碍 (iRBD) 患者表现出移动健康技术检测到的微妙转变化,表明早期运动变化. 这些发现可能有助于预测帕金森氏症.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 生物医学工程 生物医学工程
背景情况:
- 异常性REM睡眠行为障碍 (iRBD) 是发展帕金森病 (PD) 和其他α-synucleinopathies的重要危险因素.
- 在iRBD患者中早期发现前进性帕金森症的症状对于及时干预至关重要.
- 微妙的运动变化,特别是在转身时,可能会在帕金森症的临床诊断之前出现.
研究的目的:
- 通过使用移动医疗技术,调查iRBD患者的微妙转身变化,而没有下值帕金森症.
- 为了比较iRBD患者,以前没有服用过药物的PD患者和健康对照患者之间的转向参数.
- 评估移动卫生技术在识别iRBD早期运动缺陷方面的实用性.
主要方法:
- 一项前性横截面研究包括148名参与者:23名iRBD患者,60名以前未服用药物的PD患者和65名年龄匹配的对照.
- 参与者接受了多维评估,包括认知和非运动症状.
- 使用移动健康技术 (下背部传感器) 在正常和快速速度进行了定时起动测试 (TUG),以测量转时间,平均和峰值角速度.
主要成果:
- 帕金森病患者在正常和快速TUGs中表现出明显更长的转时间和较低的平均/峰值角速度,与对照组相比.
- 与对照组相比,iRBD参与者表现出明显更长的转时间和较低的平均/峰值角速度,但仅在正常速度的TUG.
- 移动健康技术成功地在正常速度TUG期间在iRBD受试者中发现了微妙的转向变化,但在高速速度TUG期间没有.
结论:
- 移动健康技术可以在iRBD个体中检测到微妙的转异常,即使没有明显的帕金森症.
- 这些客观转向参数可以作为预测iRBD中的PD转换风险的潜在生物标志物.
- 需要进行进一步的纵向研究,以验证这些参数在追踪先发性帕金森病中运动进展中的价值.
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