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Updated: Jun 30, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
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对SARS-CoV-2菌株的进化关系进行集群分析

Xiangzhong Chen1, Mingzhao Wang1, Xinglin Liu1

  • 1School of Computer Science, Shaanxi Normal University, Xian, 710119, China.

Scientific reports
|March 19, 2024
PubMed
概括

在SARS-CoV-2基因组数据的层次聚类中,确定了像BF.28和BE.1.1.1这样的独特菌株作为潜在的进化来源. 其他菌株显示免疫逃避和传播能力增加,需要密切监测.

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
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