神经感应的能力是通过通过Yap的水静压控制的
Delan N Alasaadi1, Lucas Alvizi1, Jonas Hartmann1
1Department of Cell and Developmental Biology, University College London, London, UK.
Nature cell biology
|March 19, 2024
概括
胚胎的水静压调节组织能力. 增加的压力通过影响Yap和Wnt信号传递来抑制神经细胞诱导,这是脊椎动物中保存的机制.
科学领域:
- 发育生物学是发展生物学.
- 细胞力学 细胞力学
- 分子信号传递是什么?
背景情况:
- 胚胎诱导涉及信号响应的组织相互作用,但组织能力调节的理解很差.
- 虽然研究了分子信号,但组织力学对胚胎能力的影响仍然未被探索.
- 神经细胞是关键的胚胎细胞群,对脊椎动物发育至关重要.
研究的目的:
- 研究水静压在调节神经细胞能力中的作用.
- 探索液压压力影响神经感应的分子机制.
- 为了确定这种机制是否在脊椎动物物种中得到保护.
主要方法:
- 在体内操纵脊椎动物胚胎中的布拉斯托科尔水静压.
- 分析Yap信号和Wnt激活路径,以应对压力变化.
- 在两动物,小鼠和人类细胞模型中进行比较研究.
主要成果:
- 随着Blastocoel的水静压增加,神经的能力会下降.
- 升高的水静压抑制了Yap信号,并损害了Wnt的激活.
- 在各种脊椎动物模型中,水静压被证明可以控制神经感应.
结论:
- 组织力学,特别是水静压,在调节胚胎能力方面发挥着至关重要的作用.
- 液压压力影响关键信号通路 (Yap,Wnt) 来控制神经引.
- 这种机械调节能力的机制在脊椎动物的整个发育过程中都保持着.
相关概念视频
Determination
18.5K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.5K
Neurulation
41.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.9K


