制阻燃剂 (BFR) 对美国成年人的肺功能的影响:基于NHANES (2007-2012) 的横截面研究
Haiyan Mao1, Tong Lin1, Shanshan Huang1
1Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, 315100, China.
Scientific reports
|March 19, 2024
概括
暴露于制阻燃剂 (BFRs) 与肺功能受损有关. 在一项人口研究中,特定BFRs (如PBDE47) 和联合BFRs的较高血清水平与呼吸系统功能障碍有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肺部病理学 肺部病理学
背景情况:
- 制阻燃剂 (BFR) 是广泛使用的工业化学品.
- 人们担心BFRs对健康的不利影响,特别是对呼吸系统的不利影响.
- 基于人群的BFR和肺功能数据有限.
研究的目的:
- 为了研究血清BFR度与肺功能之间的关联.
- 检查特定BFR及其混合物对呼吸系统功能障碍的影响.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 分析了各种BFR的血清度,包括PBDE47,PBDE183和PBDE209.
- 评估肺呼吸功能并进行调整的相关性分析.
主要成果:
- 某些BFR的血清度升高与肺呼吸系统功能障碍显著相关.
- 在PBDE47,PBDE183,PBDE209和呼吸系统功能障碍之间观察到正相关性.
- 联合BFR暴露与通风受损有积极的关系,PBDE47是主要的贡献者.
结论:
- 对BFR的个人和联合暴露都会损害肺透气功能.
- 研究结果强调了BFR对肺部健康的不利影响.
- 需要进一步的大规模纵向研究来证实这些关联.
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