相关实验视频

Updated: Jun 30, 2025

Human Egg Maturity Assessment and Its Clinical Application

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

人类基因相II卵细胞具有狭窄的周周细胞空间,其受精,发育和怀孕潜力较差

Masashi Shioya^1,2, Miki Okabe-Kinoshita³, Tatsuya Kobayashi^4,5

¹Takahashi Women's Clinic, 18-14-6F Shinmachi, Chuo-ku, Chiba, 260-0028, Japan. khg032638@gmail.com.

Journal of assisted reproduction and genetics

|March 19, 2024

概括

卵细胞具有狭窄的周周细胞空间 (NPVS) 显示受精和胚胎发育潜力降低. 这影响了临床怀孕率,凸显了NPVS作为体外受精结果的重要因素.

科学领域:

生殖生物学生殖生物学
在试管婴儿受精体外受精.
胚胎学胚胎学

背景情况:

周位细胞空间 (PVS) 对于卵细胞受精和早期发育至关重要.
PVS大小的变化,例如狭窄的PVS (NPVS),可能会影响卵细胞质量和生殖潜力.

研究的目的:

调查狭窄周围细胞空间 (NPVS) 对卵细胞受精,胚胎发育和随后怀孕结果的影响.
为了比较NPVS的卵细胞的生殖潜力与正常PVS的卵细胞的生殖潜力.

主要方法:

在细胞内精子注射 (ICSI) 时,卵子被分类为具有狭窄PVS (NPVS) 或非狭窄PVS (非NPVS).
使用逻辑回归,在NPVS和非NPVS卵细胞之间比较了受精,二核前核 (2PN) 形成,分裂和胚胎细胞发育率.
在单次玻璃化加热胚胎移植后,分析了从NPVS和非NPVS卵细胞中衍生出来的芽细胞的临床怀孕率.

主要成果:

与非NPVS卵细胞相比,NPVS卵细胞表现出明显更高的退化率和0PN,较低的2PN率.
来自NPVS卵细胞的胚胎显示了分裂和胚胎细胞发育的可能性降低 (加德纳标准CC-AA).
从NPVS卵细胞发育的芽细胞与显著较低的临床怀孕率有关.

结论:

狭窄周周细胞空间 (NPVS) 的卵细胞显示受精和发育能力下降.
卵细胞中的NPVS与IVF周期中实现临床怀孕的可能性较低有关.
识别NPVS卵细胞可能有助于预测试管婴儿成功和优化治疗策略.

关键词:

不正常的卵子细胞.形态变异学 (Dysmorphology) 是一种关于形态变异的现象.胚胎发育的发展卵细胞评估评价周围生命线空间的空间.

更多相关视频

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes

Published on: September 13, 2022

相关概念视频

Meiosis II

Meiosis II

Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

Meiosis vs. Mitosis

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...

Fertilization

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...