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相关概念视频

Network Covalent Solids02:18

Network Covalent Solids

Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
Ampere's Law: Problem-Solving01:31

Ampere's Law: Problem-Solving

Ampere's law states that for any closed looped path, the line integral of the magnetic field along the path equals the vacuum permeability times the current enclosed in the loop. If the fingers of the right hand curl along the direction of the integration path, the current in the direction of the thumb is considered positive. The current opposite to the thumb direction is considered negative.
Specific steps need to be considered while calculating the symmetric magnetic field distribution using...
Ampere-Maxwell's Law: Problem-Solving01:17

Ampere-Maxwell's Law: Problem-Solving

A parallel-plate capacitor with capacitance C, whose plates have area A and separation distance d, is connected to a resistor R and a battery of voltage V. The current starts to flow at t = 0. What is the displacement current between the capacitor plates at time t? From the properties of the capacitor, what is the corresponding real current?
To solve the problem, we can use the equations from the analysis of an RC circuit and Maxwell's version of Ampère's law.
For the first part of the problem,...
Numerical Calculations01:24

Numerical Calculations

In engineering applications, the representation of the numerical value is critical. Presenting or reporting the answer is one of the essential parts of engineering practices. Numerical calculations are performed using handheld calculators or computers since numerically accurate answers are always preferred.
The solution to a problem is obtained using different methods. While manually solving algebraic symbols is one of the most common methods, the graphical method is often preferred. Computers...
Design Example: Capacitance Multiplier Circuit01:20

Design Example: Capacitance Multiplier Circuit

In integrated circuit technology, a capacitance multiplier is often utilized to produce a larger capacitance value when a small physical capacitance falls short. This is achieved by a circuit that multiplies capacitance values by a factor of up to 1000, such that a 10-pF capacitor can replicate the performance of a 100-nF capacitor.
The circuit illustrated in Figure 1 below incorporates two op-amps, with the first operating as a voltage follower and the second acting as an inverting amplifier.
Calculation of Volume of Solids by Integration01:27

Calculation of Volume of Solids by Integration

Volume calculation often begins with simple geometric solids. For example, the volume of a rectangular box is obtained by multiplying the area of its base by its height. This straightforward approach relies on the fact that the cross-sectional area of the box remains constant throughout its length. Many real-world objects, however, do not have uniform cross-sections, and their volumes cannot be determined using elementary geometric formulas.To address this limitation, the Slicing Method...

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相关实验视频

Updated: May 15, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

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固体结合的高通量计算选

Xin Qi1, Jim Pfaendtner2

  • 1Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03784, United States.

Journal of chemical theory and computation
|March 19, 2024
PubMed
概括
此摘要是机器生成的。

这项研究引入了一个新的计算模型,可以快速预测固体结合 (SBPs) 如何附着在表面. 这种快速估计加速了用于纳米材料制造的新的发现.

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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
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相关实验视频

Last Updated: May 15, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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科学领域:

  • 生物矿物化和纳米材料科学
  • 计算化学和的设计设计.

背景情况:

  • 固体结合 (SBPs) 是受自然生物矿物化的启发,用于创建纳米结构.
  • 设计具有特定结合性质的SBP传统上需要密集的方法,如菌体显示.
  • 对于SBP序列的现有计算验证方法往往非常昂贵.

研究的目的:

  • 开发一种快速且具有成本效益的计算模型,用于估计SBP与固体表面结合的自由能量.
  • 为了使SBP能够更快地选和设计针对特定应用的SBP.
  • 为了降低与SBP序列验证相关的计算成本.

主要方法:

  • 开发了一种新型模型,以基于稳定结构集合的残留贡献来估计结合的自由能量.
  • 利用热力学稳定的结构的统计分析.
  • 通过使用五种具有不同亲和度和长度的结来验证模型.

主要成果:

  • 该模型准确且可靠地估计了各种化学成分和结合强度的结合自由能量.
  • 与传统的增强采样方法相比,实现了低至3%的计算成本.
  • 证明了该模型对结的有效性.

结论:

  • 新模型显著加快了SBP与表面结合的自由能量的估计.
  • 为现有的验证技术提供了具有成本效益的替代方案.
  • 具有很高的潜力,可以集成到高吞吐量选和机器学习算法,用于SBP发现.