经过单次触发疼痛后,古典三角神经疼痛患者的局部大脑功能的变化趋势
Juncheng Yan1, Luoyu Wang2,3, Lei Pan2
1Department of Rehabilitation, Hangzhou First People's Hospital, 310000, Hangzhou, China.
BMC medical imaging
|March 19, 2024
概括
三神经疼痛 (TN) 患者的区域同质性 (ReHo) 在疼痛刺激后显示时间频率变化. 大脑活动的变化持续超过30分钟,这表明功能影响持续时间长.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 功能性核磁共振成像 (MRI) 是一种功能性核磁共振成像.
背景情况:
- 三神经痛 (TN) 是一种影响三神经的慢性疼痛疾病.
- 了解TN疼痛背后的神经机制对于开发有效的治疗方法至关重要.
- 休息状态功能性MRI (fMRI) 可以揭示自发大脑活动的改变.
研究的目的:
- 研究古典三角神经疼痛 (CTN) 患者的时间和频率变化的区域同质性 (ReHo) 趋势.
- 澄清CTN患者单次疼痛刺激后ReHo的时间频率特征.
主要方法:
- 48名CTN患者在基线时接受了静止状态fMRI,刺激后5秒,刺激后30分钟.
- 静态ReHo (sReHo) 在五个频段中进行了分析.
- 动态ReHo (dReHo) 用于评估大脑活动的时间波动.
主要成果:
- 在经典和慢4频段观察到sReHo的显著变化.
- 在不同的大脑区域发生了dReHo变化,包括中脑, thalamus, putamen 和前带皮层.
- 大多数改变的ReHo趋势显示,5秒后活动减少,30分钟后刺激活动增加.
结论:
- 在CTN患者中,脑功能变化在单次疼痛刺激后持续超过30分钟.
- 在CTN患者中,ReHo在刺激后表现出明显的时间频率特征.
- 从sReHo和dReHo的补充发现提供了对CTN病理生理学的见解.
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