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用免疫疗法治疗的晚期皮肤状细胞癌中围神经扩散的评估

Karda Cavanagh¹, Luke S McLean^2,3, Annette M Lim^2,3

¹Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Cancer imaging : the official publication of the International Cancer Imaging Society

|March 19, 2024

概括

免疫疗法显示皮肤状细胞癌与周围神经扩散 (PNS) 的高响应率,根据修改的MRI标准进行评估. 这些反应与RECIST 1.1一致,表明免疫疗法.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
免疫治疗是一种免疫疗法.

背景情况:

皮肤状细胞癌 (CSCC) 经常涉及周围神经系统 (PNS) 的扩散,与糟糕的结果相关.
免疫疗法是高级CSCC的新标准,提供持久的反应.
像RECIST 1.1这样的当前标准无法捕捉PNS,需要新的评估方法.

研究的目的:

评估晚期CSCC患者的PNS对免疫治疗的放射性反应.
评估修改后的分级系统对MRI上PNS反应的有用性.
探索PNS反应,RECIST 1.1和FDG-PET/CT发现之间的相关性.

主要方法:

对20名先进的CSCC患者进行了回顾性审查,这些患者患有PNS并接受免疫治疗 (2018年4月-2022年2月).
主要结局:使用MRI<5,5-10,>10个月的分级标准对盲目放射性PNS反应的评估.
二次结果:与RECIST 1.1的相关性以及对FDG-PET/CT.的PNS的评估.

主要成果:

70%的患者在5个月后表现出PNS反应.
在MRI上PNS反应在很大程度上与>10个月的RECIST 1.1一致 (科恩的卡帕0.62).
在5/14例中,FDG-PET/CT显示可疑的PNS特征,表明敏感性有限.

结论:

修改后的MRI标准可以有效地记录CSCC中免疫疗法诱导的PNS反应.
观察到PNS对免疫疗法的高反应率,与RECIST 1.1相关.
在这种情况下,FDG-PET/CT对检测PNS的灵敏度有限.

关键词:

皮肤状细胞癌瘤免疫治疗是一种免疫疗法.周围神经神经扩散

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