儿科纵向黑色素瘤的黑色素瘤样特征:一个系统的审查和元分析
Serena Yun-Chen Tsai1,2, Claire E Hamilton2,3, Mia A Mologousis1,4
1Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pediatric dermatology
|March 19, 2024
概括
儿科纵向黑色心脏病 (LM) 经常出现异常,但很少变为恶性. 仔细的临床和皮肤镜评估可以帮助区分良性病例,减少侵入性手术的需要.
科学领域:
- 皮肤病学 皮肤病学
- 儿科瘤学 儿科瘤学
- 眼科医生 眼科 眼科
背景情况:
- 儿童的长度黑色素瘤 (LM) 可能呈现出令人担忧的特征,模仿黑色素瘤.
- 诊断不确定性经常出现,可能导致不必要的侵入性手术,如指甲活检.
研究的目的:
- 系统地审查和元分析儿科LM的临床和皮肤镜特征.
- 评估儿科LM恶性转变的风险.
主要方法:
- 对报告儿科LM (≤18岁) 的研究进行系统审查和元分析.
- 从创立到2023年2月,搜索了PubMed和Embase数据库.
- 包括至少5名儿科患者的研究;不包括非英语文章,评论和摘要.
主要成果:
- 包括来自24项研究的1391名儿科患者;神经是最常见的诊断 (86.3%).
- 共同特征包括深色带 (69.8%),多色带 (47.6%) 和伪哈森标志 (41.0%).
- 恶性转变是罕见的,只有八个in situ黑色素瘤病例,没有报告的侵入性黑色素瘤.
结论:
- 非典型的特征在儿科LM中很常见,但恶性瘤的风险非常低.
- 临床和皮肤镜评估对于识别良性特征至关重要.
- 建议进行长期随访,以适当管理儿科LM.
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