在β-thalassaemia的听力损失:一个意大利多中心病例控制研究研究
Renzo Manara1,2, Davide Brotto3, Maria Rosaria Barillari4
1Neuroradiology, Neurosciences Department, University of Padova, Padova, Italy.
British journal of haematology
|March 19, 2024
概括
听力损失在β-thalassaemia中很常见,影响了21%的患者. 这种听力损失在老年男性中更为普遍,其与疾病严重程度或化疗法的关联尚不清楚.
科学领域:
- 血液学 血液学 血液学
- 听力学 听力学是指听力学.
- 遗传学 是一个遗传学.
背景情况:
- 贝塔血症是一种遗传性血液疾病,具有复杂的健康影响.
- 在β-血病患者的听力损失并未得到充分了解.
- 之前的研究对这一群体中听力障碍的患病率和原因产生了不确定的结果.
研究的目的:
- 调查贝塔血病患者听力损失的患病率和特征.
- 为了确定与β-thalassaemia患者听力损伤相关的风险因素.
- 为了比较beta-thalassaemia患者和健康对照者之间的听力结果.
主要方法:
- 这是一项涉及376名β-thalassaemia患者和139名健康对照者的横截面研究.
- 纯音调听力测量用于评估听力功能.
- 人口,临床和实验室数据,包括化疗法,被收集和分析.
主要成果:
- 与对照组 (7.2%) 相比,贝塔血病患者 (26.6%) 的听力损失 (低听力) 的患病率明显高于对照组 (7.2%).
- 听力损失在男性中更常见,并且随着年龄的增长而增加,但与疾病表型或输血依赖性没有显著关联.
- 感觉神经听力损失是主要类型,感觉神经口听力损失的患病率在患者和对照人群之间没有差异.
结论:
- 感觉神经听力损失是beta-thalassaemia的一个重要问题,患病率约为21%.
- 年龄和男性性别被确定为这个人群中听力损失的危险因素.
- 疾病严重程度和化疗法在听力损失中的作用需要进一步调查,而在β-thalassaemia中感觉神经的意义是可疑的.
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