在精神分裂症患者中,克洛扎宾处方模式的种族差异
Spenser Barry1, L Fredrik Jarskog1, Kai Xia1
1Department of Psychology, University of North Carolina Wilmington, Wilmington (Barry); Carolina Health Informatics Program (Torpunuri) and Department of Biostatistics (Wu), University of North Carolina at Chapel Hill, Chapel Hill; North Carolina Psychiatric Research Center (Jarskog, Zeng) and Mental Health Informatics and Analytics Core (Xia, Zeng), Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill.
Psychiatric services (Washington, D.C.)
|March 19, 2024
概括
患有精神分裂症的黑人患者不太可能接受克洛札,这是对抗性病例的关键治疗方法. 这项研究强调了基于种族和社会因素的克洛扎宾处方率的差异.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 医疗保健服务研究 医疗服务研究
- 健康 公平 卫生 公平
背景情况:
- 克洛扎平是治疗耐药精神分裂症的关键治疗方法.
- 之前的研究表明,人口因素会影响克洛扎的处方率.
- 了解这些差异对于公平的患者护理至关重要.
研究的目的:
- 调查种族,健康的社会决定因素 (SVI),性别,农村和护理模式对精神分裂症患者克洛扎宾处方率的影响.
- 为了确定与接受克洛扎与其他抗精神病药物相关的因素.
主要方法:
- 在3,160名成年精神分裂症患者 (2015年10月 - 2021年11月) 的横截面观察研究.
- 使用电子健康记录和社会脆弱性指数 (SVI).
- 使用后勤回归和灵敏度分析来比较患者组.
主要成果:
- 白人种族,较高的社区少数民族地位/语言SVI分数,以及更长的治疗时间与增加克洛扎的可能性有关.
- 与白人患者相比,黑人患者接受克洛扎宾的可能性较低.
- 性别,农村地区,首次诊断时的年龄和种族并没有显著影响克洛扎的处方率.
结论:
- 在对精神分裂症患者的克洛扎宾处方中存在显著的种族差异.
- 健康和治疗持续时间的社会决定因素影响了克洛扎宾的使用.
- 需要进一步的研究来解决和减轻这些治疗差异,以改善结果.
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