通过UHPLC-Q-TOF-MS快速选34种表面水中的新出现的污染物
Chen-Shan Lü1,2,3, Yi-Xuan Cao1,2,3, Xiao-Xi Mu1,2,3
1School of Forensic Medicine, Shanxi Medical University, Jinzhong 030600, Shanxi Province, China.
Fa yi xue za zhi
|March 19, 2024
概括
一种新的超高性能液态染色学-四极时飞行质谱法 (UHPLC-Q-TOF-MS) 方法可以快速选表面水中的34种新出现的污染物. 这种经过验证的技术可以准确地检测微量含量,帮助环境监测工作.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
背景情况:
- 新出现的污染物对水生生态系统和人类健康构成风险.
- 对地表水中的这些污染物进行有效监测至关重要.
研究的目的:
- 开发和验证表面水中34种新出现的污染物的快速选方法.
- 为了利用超高性能液态染色学-四极时飞行质谱学 (UHPLC-Q-TOF-MS) 进行微量检测.
主要方法:
- 使用直角实验设计优化固相提取 (SPE).
- 采用了一系列Oasis® HLB和MCX SPE柱子用于提取和缩.
- 使用UHPLC与Kinetex® EVO C18柱和梯度化进行分离.
- 在"全扫描"和"目标MS/MS"模式中应用Q-TOF-MS以识别和量化污染物.
主要成果:
- 该方法对所有34种污染物都显示出良好的线性 (r > 0.97).
- 实现了低检测极限 (0.2-10 ng/L) 和高恢复率 (81.2%-119.2%).
- 在真实地表水样本中成功检测出6种新出现的污染物,范围为1.93-157.71 ng/L.
结论:
- 开发的UHPLC-Q-TOF-MS方法对于选新出现的污染物是简单,快速和有效的.
- 该方法可以在地表水中的微量水平上可靠地检测新出现的污染物.
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