临床和实验室参数与发烧发作在前24小时内复发相关:为期十年的队列研究
Massimo Luca Castellazzi1, Adriano La Vecchia1,2, Martina Scali3
1Pediatric Emergency Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Frontiers in pediatrics
|March 19, 2024
概括
高体温和较少的呼吸道感染增加了儿童早期发烧发作复发的风险. 了解这些因素可以帮助预测第一次事件后的复发概率.
科学领域:
- 儿科神经学 儿科神经学
- 紧急医疗 紧急医疗
- 临床研究 临床研究
背景情况:
- 发烧性发作在幼儿中很常见,了解复发风险因素对于临床管理至关重要.
- 发烧发作的早期复发可能会引起父母的严重焦虑,需要立即医疗照顾.
研究的目的:
- 确定与首次发作儿童发烧发作早期复发相关的临床和实验室参数.
- 确定可以帮助预测发烧发作在24小时内复发的可能性的预测因素.
主要方法:
- 一个案例系列研究包括693名患有第一次发烧的患者,不包括具有焦点特征或长时间发作 (>15分钟) 的患者.
- 收集的数据包括患者人口统计,最大体温,抗热剂使用和呼吸道感染的存在.
- 进行了统计分析,包括单变量和多变量评估,以确定与复发的显著关联.
主要成果:
- 8% (52/693) 的患者在24小时内出现复发.
- 在单变量分析中,较高的最大体温 (≥39°C) 和增加的抗发烧剂使用与复发相关.
- 多变量分析证实了体温升高和复发之间的直接关联,以及与呼吸道感染的反向关联. 在多变量模型中,抗发烧药的使用不是一个显著的预测因素.
结论:
- 升高的体温是早期发烧发作复发的重要预测因素.
- 呼吸道感染的存在似乎是防止复发的保护因素.
- 这些发现可以帮助临床医生预测儿科患者发烧复发的可能性.
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