在患有前列腺癌和没有前列腺癌的男性中,肠道微生物群概况和微生物群类固醇激素生物合成的差异
Sofia Kalinen1,2, Teemu Kallonen2,3, Marianne Gunell2,3
1Research Center for Infections and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland.
European urology open science
|March 19, 2024
概括
肠道微生物群在前列腺癌 (PCa) 患者中显著不同,特定的微生物功能可能会影响疾病的发展. 这些肠道细菌的变化可能会将环境因素与PCa发病率联系起来.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 前列腺癌 (PCa) 发病率在地理位置上有所不同,可能是由于生活方式和遗传因素.
- 肠道微生物群在PCa发展和进展中的作用在很大程度上仍然不清楚.
- 肠道微生物群已与各种癌症有关,但与PCa的特定关联需要进一步调查.
研究的目的:
- 在怀疑患有前列腺癌的男性中描述肠道微生物群组成和功能概况.
- 为了确定与前列腺癌诊断相关的特定微生物变化.
- 探索将肠道微生物群与PCa联系起来的潜在机制,包括类固醇激素代谢.
主要方法:
- 一个前性的多中心临床试验 (NCT02241122),涉及181名疑似PCa.的男性.
- 使用16SrRNA测序分析了肠道微生物群的特征.
- 进行了差异丰度分析,多样性指标和预测功能分析.
主要成果:
- 在PCa患者和良性个体之间,微生物群的组成和多样性显著不同.
- 在PCa患者中,*Prevotella 9*属更为丰富.
- 预测性功能分析表明,PCa相关微生物群中的5-α-减少酶活性,铜吸收和视网醇代谢增加.
结论:
- 肠道微生物群的组成和功能在前列腺癌中发生显著变化.
- 微生物5-α-减少酶,铜吸收和视网醇代谢代表了将肠道微生物群与PCa联系起来的潜在机制.
- 这些发现支持了肠道微生物群可能调解环境因素对PCa发病率的影响的假设.
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