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膀癌中外体非编码RNA的诊断和预后潜力:系统性审查和元分析

Yani Chen¹, Kesong Shi¹, Xinyao Fu¹

¹State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia, China.

Frontiers in oncology

|March 19, 2024

概括

非编码RNAs (ncRNAs) 显示为膀癌诊断和预后的生物标志物具有前途. 较高的ncRNA表达与更好的整体存活率和无疾病存活率有关,表明潜在的临床实用性.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
分子生物学分子生物学
生物标志物生物标志物

背景情况:

膀癌是主要的泌尿器官恶性瘤,对公共卫生产生重大影响.
非编码RNAs (ncRNAs) 正在成为膀癌的潜在诊断和预后生物标志物.
在膀癌中ncRNAs的确切作用需要进一步阐明.

研究的目的:

进行元分析以澄清ncRNAs在膀癌中的意义和相关性.
为了评估ncRNAs的诊断性能.
评估ncRNAs与整体存活率 (OS) 和无病存活率 (DFS) 的关联.

主要方法:

对ncRNA诊断性能和生存关联的研究进行系统的元分析.
提取和聚合危险比率,灵敏度,特异性和诊断几率比率.
使用Deeks的漏斗图和灵敏度分析评估出版偏差.

主要成果:

增加的ncRNA表达与改善的OS (HR=0.82) 和DFS (HR=0.86) 相相关.
诊断分析显示,聚合灵敏度为0.76,特异性为0.83,诊断几率比为2.71,AUC为0.85.
分析证实了ncRNA表达和膀癌结局之间的显著关联.

结论:

外体ncRNAs在膀癌的诊断和预后中显示出潜在的临床实用性.
ncRNAs作为预测膀癌患者生存结果的生物标志物具有前途.
进一步的研究是必要的,以充分确定ncRNAs在个性化膀癌症管理中的作用.

关键词:

膀癌:膀癌是一种癌症.诊断诊断诊断诊断诊断诊断这是一个元分析.没有编码的RNAs.预后预后预后

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