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Updated: Jun 30, 2025

Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays
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Published on: June 13, 2019

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在中国患有晚期固体瘤的中国患者中,口服ORIN1001的群体药动力学模型

Xiaoqing Li1, Yunhai Bo1, Qingping Zeng2

  • 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), National Drug Clinical Trial Center, Peking University Cancer Hospital and Institute, Beijing, China.

Frontiers in pharmacology
|March 19, 2024
PubMed
概括

一个IRE1-α抑制剂ORIN1001的第一个群体药理动力学 (PopPK) 模型确定了总胆红素和瘦体重作为影响药物暴露的关键因素. 这种模型有助于ORIN1001在未来的癌症治疗开发.

关键词:
在ORIN1001中,我们使用的是ORIN1001.模型建设模型建设.模型评价模型评价模拟模型的模拟模型人口的药理动力学模型.

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