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Updated: Jun 30, 2025

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
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探索奥西默蒂尼布的种族间和患者间的变异性和最佳剂量:一种基于生理学的药理动力学建模方法

Feng Liang1, Yimei Zhang1, Qian Xue1

  • 1Bethune International Peace Hospital, Shijiazhuang, China.

Frontiers in pharmacology
|March 19, 2024
PubMed
概括

这项研究开发了一种基于生理学的药理动力学 (PBPK) 模型,用于奥西默提尼布 (OSI) 预测药物度和疗效. 该模型确定了不同人群的最佳剂量方案,并考虑了种族和患者特异性的差异.

关键词:
在PBPK模型中,种族差异是种族的差异.患者间的可变性.最优的剂量方案最优的剂量方案奥西米尔丁尼布 (osimertinib) 是一种

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