细胞非自主控制自和新陈代谢由质细胞
Melissa G Metcalf1,2, Samira Monshietehadi1,2, Arushi Sahay1,2
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
iScience
|March 19, 2024
概括
质XBP-1s通过重新编程脂质新陈代谢并激活C. elegans的自性来非自主地增强生物体的蛋白质稳定和寿命.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 衰老研究研究 衰老研究
背景情况:
- 质细胞,特别是星球细胞,支持神经元的健康,并防止损伤.
- 以前,在C. elegans*中发现了通过XBP-1s (UPRER转录因子) 调节蛋白质稳定和长寿的星球细胞样细胞质.
- 这种质XBP-1s通过神经激活了肠道细胞中的未折叠蛋白质反应 (UPRER).
研究的目的:
- 调查质XBP-1s通过哪些非自主机制影响生物体蛋白质稳定和寿命.
- 确定质细胞在调节自和脂质新陈代谢中的作用,超出细胞自主功能.
主要方法:
- 使用C. elegans作为一个模型生物.
- 操纵了GLIA中的UPRER转录因子XBP-1s的表达.
- 分析了生物体蛋白质稳定,寿命,脂质新陈代谢和自激活的变化.
主要成果:
- 质XBP-1s通过细胞非自主通路增强蛋白质静止和寿命.
- 质XBP-1s重新编程生物体的脂质代谢,并激活自.
- 质XBP-1s在肠道中调节转录因子HLH-30/TFEB,促进自和脂质代谢.
结论:
- 质细胞在调节周边脂质代谢和自方面发挥着新的作用.
- 质信号通过HLH-30/TFEB通路影响器官健康和机体衰老.
- 这项研究突出了质细胞在维持生物体平衡中的非自主功能.
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