血清FT3/FT4,但不是TSH与美国人口的手握强度有关:来自NHANESES的证据
Zhizhuo Wang1, Peiyun Wu1, Jing Yang1
1Department of Rehabilitation Medicine, School of Health, Fujian Medical University, Fuzhou, China.
Frontiers in endocrinology
|March 19, 2024
概括
甲状腺激素自由T3/自由T4,而不是TSH,与美国中年成人手握强度相关. 这种关联因性别和年龄而异,这表明甲状腺功能会影响肌肉力量.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 肌肉骨健康 肌肉骨健康
背景情况:
- 目前对甲状腺功能和肌肉力量的研究有限,主要来自亚洲人群,结果相互矛盾.
- 手握强度 (HGS) 是整体肌肉强度和功能状态的关键指标.
研究的目的:
- 为了研究甲状腺功能和手握强度在美国人口中存在的关联.
- 探索甲状腺激素和肌肉力量之间的特定年龄和性别关系.
主要方法:
- 分析了来自国家健康和营养检查调查 (NHANES) 的1067名参与者.
- 甲状腺功能通过竞争性结合性免疫酶测定进行评估;使用动力计测量HGS.
- 权重多重线性回归和受限立方线用于分析关联.
主要成果:
- 自由三甲状腺素/自由甲状腺素 (FT3/FT4) 在中年人群 (45-64岁) 中,独立于TSH,显示出与HGS的积极关联.
- 在中年人群中,FT3/FT4和HGS之间的这种积极关联在男性和女性中显著.
- 在总人口中观察到FT3/FT4和HGS之间的非线性关联. 低HGS的老年男性FT3/FT4水平较低,而低HGS的老年女性TSH水平较高.
结论:
- 甲状腺激素FT3/FT4,而不是TSH,在美国中年成人中与HGS有积极的联系.
- 甲状腺功能和肌肉强度之间的关系因年龄和性别而异,需要进一步调查.
- 需要进行纵向研究来确定甲状腺功能与肌肉力量之间的因果关系.
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