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Updated: Jun 30, 2025

Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
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基于冷电子显微镜的药物设计.

Ecenur Cebi1, Joohyun Lee1, Vinod Kumar Subramani1

  • 1Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.

Frontiers in molecular biosciences
|March 19, 2024
PubMed
概括

基于结构的药物设计 (SBDD) 被冷电子显微镜 (cryo-EM) 增强,这是X射线结晶学的一个强大的替代方案. 化EM为发现更有效治疗疾病的药物提供了新的潜力.

关键词:
冷电子显微镜的使用方法药物开发是药物的发展.高分辨率的高分辨率显示器单个粒子分析基于结构的药物设计.

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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