在运动后,Cordyceps sinensis加速了干细胞的招募到人类骨肌肉中
Luthfia Dewi1,2, Yu-Chieh Liao1, Wei-Horng Jean3
1Laboratory of Exercise Biochemistry, University of Taipei, Tianmu Campus, Taipei, Taiwan. kuochiahua@gmail.com.
Food & function
|March 19, 2024
概括
补充Cordyceps sinensis可以通过增强干细胞招募来加速运动后的肌肉修复. 这项研究表明,Cordyceps可以减少肌肉损伤,并促进人类更快的再生.
科学领域:
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
背景情况:
- 科尔迪塞普斯 (Cordyceps sinensis) 是以免疫调节性质而闻名的植物.
- 科尔迪塞普斯对肌干细胞运动后反应的影响尚不清楚.
- 了解肌肉修复机制对于运动恢复和伤害管理至关重要.
研究的目的:
- 调查Cordyceps补充剂在高强度间歇运动 (HIIE) 后对肌肉细胞透和干细胞活性的影响.
- 为了确定Cordyceps是否影响人类骨肌肉中的CD34+细胞招募和Pax7+细胞扩张.
- 评估Cordyceps在运动引起的肌肉损伤解决中的作用.
主要方法:
- 一项随机,双盲,安慰剂控制的交叉研究,涉及14名健康成年人.
- 在HIIE之前,参与者接受了Cordyceps sinensis或安慰剂.
- 分析了Vastus lateralis肌肉活组织以检测细胞透,CD34+和Pax7+细胞以及VEGF mRNA.
主要成果:
- HIIE增加了VEGF mRNA和死细胞透,而Cordyceps减弱了这种作用.
- 皮质素补充剂在运动后3小时加速了CD34+细胞向肌肉组织的招募.
- 这种早期的干细胞反应导致Pax7+细胞增加了四倍,表明肌肉再生得到了增强.
结论:
- 补充Cordyceps sinensis可以加速人类运动引起的肌肉损伤的解决.
- 再生效应与干细胞在受损肌肉部位的增强和早期招募有关.
- 这项研究为Cordyceps在体育恢复和肌肉修复中的作用提供了新的证据.
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