药物诱导的间歇性肺病:对临床难题的叙述性回顾
Megan Harrison1, Grace Kavanagh1, Tamera J Corte2
1Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Expert review of respiratory medicine
|March 19, 2024
概括
药物诱导的间歇性肺病 (DI-ILD) 正在增加,影响患有癌症和炎症性疾病的患者. 早期检测和停止违规药物是改善这种情况结果的关键.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 药物诱导间歇性肺病 (DI-ILD) 的发生率正在增加,这是由于癌症和炎症疾病的新疗法.
- 儿童消化障碍的呈现和发病在个体之间有很大差异,即使使用相同的药物.
- 临床警和迅速戒药对于管理DI-ILD和改善患者预后至关重要.
研究的目的:
- 提供关于DI-ILD的流行病学,危险因素,发病,诊断,治疗和预后的全面审查.
- 详细介绍与DI-ILD相关的特定药物,包括免疫检查点抑制剂,CAR-T细胞疗法,甲铁和阿米奥达龙.
- 探索药物遗传学分析在评估肺毒性风险方面的潜在作用.
主要方法:
- 从PubMed和Medline搜索到2023年9月的研究文章的系统审查.
- 关于DI-ILD相关文献的总结.
- 详细讨论特定的药物类别和涉及DI-ILD的药物.
主要成果:
- DI-ILD是呼吸障碍的日益严重的原因,影响生活质量和生存.
- 呼吸系统损害和对潜在疾病的治疗中断会对患者产生负面影响.
- 了解和警与药物相关的肺毒性在医学领域至关重要.
结论:
- 儿童失能症是一个重大的临床挑战,需要提高认识和主动管理.
- 药物遗传学方法可能为预测和减轻DI-ILD风险提供未来的策略.
- 及时干预,包括戒毒,仍然是有效的DI-ILD管理的基石.
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