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Updated: Jun 30, 2025

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
在COVID-19中较低与较高的氧气目标和没有生命支持的生存日:HOT-COVID随机临床试验
Frederik M Nielsen1,2, Thomas L Klitgaard1, Martin Siegemund3
1Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.
在ICU中降低COVID-19患者的氧气水平改善了结果. 与90mmHg相比,目标Pao2为60mmHg,导致没有生命支持的生存日数增加.
科学领域:
- 危急护理医学
- 肺病学
- 传染性疾病
背景情况:
- 对于严重低氧症的COVID-19患者来说,补充氧气是标准的.
- 然而,较低的氧气剂量可能有临床益处.
研究的目的:
- 在COVID-19和严重低氧症的重症监护室 (ICU) 患者中,针对较低的Pao2 (60 mm Hg) 与较高的Pao2 (90 mm Hg) 的效果进行比较.
主要方法:
- 一项多中心随机临床试验涉及726名欧洲ICU的成年COVID-19患者.
- 患者被随机分配到60mmHg (n=365) 或90mmHg (n=361) 的Pao2目标,长达90天.
- 主要结果是90天没有生命支持的生存日.
主要成果:
- 低氧化率组 (Pao2 60 mm Hg) 在没有生命支持的情况下生存的中位数为80.0天,而高氧化率组 (Pao2 90 mm Hg) 则为72.0天 (P=.009).
- 在90天的死亡率为低氧化组的30. 2%,高氧化组的34. 7% (P=.
- 在严重的不良事件或出院的生存日数中没有发现显著差异.
结论:
- 针对COVID-19和严重低氧症的ICU患者的Pao2目标,与针对90mmHg的目标相比,导致没有生命支持的生存日数更多.
- 这表明保守氧气治疗对这一患者群体有潜在的益处.
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