与高剂量甲状腺素诱导的毒性相关的危险因素
Wenshu Li1,2, Jiayi Mo1,2, Zhilin Yang1,2
1Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China.
Expert opinion on drug metabolism & toxicology
|March 19, 2024
概括
识别高剂量甲状腺醇 (HDMTX) 毒性的早期风险因素对于个性化癌症治疗至关重要. 本综述综合了诸如药物相互作用和遗传变异等因素,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 遗传学 是一个遗传学.
背景情况:
- 高剂量甲状腺酸盐 (HDMTX) 治疗对于瘤至关重要,但由于可变的药理动力学和不良影响,它存在挑战.
- 个体化的患者因素显著影响HDMTX的疗效和毒性.
- 早期识别毒性风险对于优化治疗策略至关重要.
研究的目的:
- 为了确定高剂量甲状腺 (HDMTX) 诱导的毒性早期风险因素.
- 为了为接受HDMTX治疗的患者提供个性化的治疗方法.
- 用HDMTX.改善治疗瘤的治疗结果.
主要方法:
- 对PubMed和Cochrane数据库进行了系统审查.
- 包括标准包括审查,临床试验和现实世界的分析.
- 手动搜索和引用审查补充了数据库搜索.
主要成果:
- 确定的风险因素包括MTX暴露,药物相互作用和患者人口统计.
- 血清白蛋白,尿液pH和血清等生物化学因素是重要的.
- 遗传多态性 (例如,SLCO1B1,MTHFR,ARID5B,UGT1A1,PNPLA3) 和表观遗传学在MTX毒性中发挥作用.
结论:
- 本综述提供了对HDMTX毒性风险因素的全面了解.
- 这些因素的早期识别有助于研究人员和临床医生管理HDMTX治疗.
- 基于已识别的风险的个性化治疗策略可以优化血液恶性瘤的治疗结果.
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