相关实验视频

Updated: Jun 30, 2025

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

对帕金森病单边下体内核深脑刺激的差异性认知效应

Victor A Del Bene^1,2, Roy C Martin^1,2, Sarah A Brinkerhoff¹

¹Department of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.

Annals of neurology

|March 19, 2024

概括

针对亚thalamic核 (STN) 的深度大脑刺激 (DBS) 在定向和环类型之间没有区别. 然而,单边右STN DBS改善了帕金森病患者的口语流性和响应抑制.

科学领域:

神经科学是一个神经科学.
神经外科神经外科
认知科学认知科学

背景情况:

脑下核深度大脑刺激 (STN DBS) 是高级帕金森病的治疗选择.
不同STN DBS配置的认知效应,特别是定向与环电极的认知效应,仍然不完全理解.

研究的目的:

在晚期帕金森病患者中,比较单边定向与环状STN DBS的认知结果.
研究刺激半球对认知功能的影响.

主要方法:

一项随机,双盲,交叉研究,涉及31名帕金森病患者接受单边STN DBS.
认知评估包括口语流,听觉-口语记忆和响应抑制.
混合线性模型分析了刺激类型和植入半球的影响.

主要成果:

在定向和环状STN DBS之间没有发现显著的群体级认知差异.
植入半球显著影响认知:左侧STN DBS与口语流性下降有关,而右侧STN DBS则改善了这种情况.
右STN DBS也增强了响应抑制,而延迟回忆随着时间的推移而略有下降,无论半球.

结论:

单边STN DBS导向配置 (定向与环) 并没有对认知表现产生差异性影响.
认知效应因半球而异:左侧STN DBS恶化了口语流性,而右侧STN DBS改善了口语流性和响应抑制.
单边右侧STN DBS可能在特定的帕金森病患者中提供认知益处,这些患者有右侧运动症状.

更多相关视频

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

相关概念视频

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.