准新陈代谢以改善CAR-T细胞的治疗疗效
Shasha Liu1, Yuyu Zhao1,2, Yaoxin Gao1
1Biotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Chinese medical journal
|March 19, 2024
概括
化学抗原受体T (CAR-T) 细胞疗法对血液癌症有希望,但与固体瘤作斗争. 向瘤代谢是克服挑战和改善固体瘤中CAR-T细胞有效性的关键.
科学领域:
- 免疫治疗是一种免疫疗法.
- 癌症新陈代谢 癌症新陈代谢
- 细胞生物学 细胞生物学
背景情况:
- 化学抗原受体T (CAR-T) 细胞疗法对血液瘤有效.
- 在治疗固体瘤方面,CAR-T细胞疗法面临着重大挑战.
- 瘤微环境的代谢场景会损害CAR-T细胞的功能.
研究的目的:
- 审查代谢物如何影响瘤微环境中的T细胞活性.
- 分析CAR-T细胞治疗固体瘤的现有局限性.
- 提出代谢向策略,以加强对固体瘤的CAR-T细胞治疗.
主要方法:
- 关于CAR-T细胞治疗和瘤代谢的文献综述.
- 对影响T细胞功能的代谢因素的分析.
- 确定克服代谢抵抗的策略.
主要成果:
- 代谢竞争和异常的瘤微环境抑制了CAR-T细胞的增殖和功能.
- 关键因素包括营养缺乏,低pH值,缺氧和免疫抑制代谢物.
- 代谢失调阻碍了T细胞介导的瘤杀伤.
结论:
- 向瘤代谢对于改善CAR-T细胞在固体瘤中的疗效至关重要.
- 需要重新建立CAR-T细胞代谢适应性的策略.
- 克服代谢障碍可能会解锁固体瘤的CAR-T细胞疗法.
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:27Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K