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Updated: Jun 30, 2025

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自动化胰岛素输送时代的时间范围分析:白天和夜晚的目标应该是相同的吗?
Ariana Maia1, David Subias Andujar2,3, Cristina Yuste2,3
1Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar Universitário de Santo António, Porto, Portugal.
Journal of diabetes science and technology
|March 19, 2024
概括
在1型糖尿病患者的混合闭环系统 (HCLS) 中,重新计算范围内的时间 (TIR) 以更严格的夜间葡萄糖目标,显著降低了传统的TIR. 这凸显了需要个性化的血糖控制策略,超越目前的指标.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 生物医学工程 生物医学工程
背景情况:
- 混合闭环系统 (HCLS) 显示了改善的夜间血糖控制.
- 传统的时间范围 (TIR) 可能不能完全代表最佳的血糖控制.
研究的目的:
- 将传统的TIR (70-180 mg/dL) 与重新计算的TIR (RTIR) 进行比较,使用更严格的夜间目标 (70-140 mg/dL).
- 评估调整的夜间葡萄糖目标对TIR在使用HCLS的T1DM患者的影响.
主要方法:
- 对22名使用Tandem t:slim X2控制-IQ HCLS的成年T1DM患者进行了回顾性研究.
- 来自Tidepool平台的14天Dexcom G6 CGM数据的分析.
- 传统TIR和RTIR指标的比较.
主要成果:
- 传统TIR的平均值为68.7%,而RTIR的平均值为60.3% (下降8.4%).
- 当应用更严格的夜间葡萄糖目标时,观察到TIR显著减少.
- 没有发现百分比差异和RTIR之间的相关性,即使在具有低常规TIR的患者中也是如此.
结论:
- 目前的传统TIR指标可能不足以在HCLS的T1DM患者中实现最佳的血糖控制.
- 在等待进一步的研究之前,建议对葡萄糖目标采取个性化的方法.
- 更严格的夜间葡萄糖目标显著影响整体TIR计算.
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