肥胖与晚期乳腺癌中免疫抑制ILC2s-MDSCs轴相关
Wei Liu1,2,3,4,5,6, Bingyu Li2,3,4, Dan Liu2,3,4
1School of Public Health, Xinjiang Medical University, Urumqi, People's Republic of China.
Immunity, inflammation and disease
|March 19, 2024
概括
肥胖可能会通过增强免疫抑制性ILC2-MDSC轴来恶化乳腺癌. 干白素-5 (IL-5) 在这种相互作用中显得至关重要,特别是在三阴性乳腺癌 (TNBC) 中.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 免疫细胞和癌症进展之间的相互作用在与肥胖有关的恶性瘤中至关重要.
- 第2组先天性淋巴细胞 (ILC2) 和髓质衍生抑制细胞 (MDSC) 是关键的免疫参与者,参与瘤微环境.
- 在肥胖和乳腺癌的背景下了解它们的轴对治疗进步至关重要.
研究的目的:
- 调查ILC2-MDSC轴与乳腺癌复发和转移患者的肥胖之间的关联.
- 探索乳腺癌患者体质指数 (BMI),免疫细胞群 (ILC2s,MDSCs) 和细胞因子概况之间的相关性.
主要方法:
- 分析了58名乳腺癌患者的血液样本,这些患者第一次复发和转移.
- 使用流细胞计量来量化ILC2s和MDSCs的比例以及血清细胞因子水平.
- 在临床特征 (BMI),细胞因子,ILC2s和MDSCs之间进行了相关性分析.
主要成果:
- 在高和正常的BMI组之间观察到ILC2s和MDSCs比例的显著差异.
- 在三阴性乳腺癌 (TNBC) 患者中,肥胖个体的ILC2和MDSC水平较高.
- 在所有乳腺癌患者中,BMI和ILC2s-MDSCs轴之间发现了正相关性,但与转移数或存活率无关.
结论:
- 肥胖可能通过增强ILC2-MDSC轴,促进晚期乳腺癌的免疫抑制环境.
- 干白素-5 (IL-5) 可能在ILC2-MDSC轴和其与TNBC肥胖的联系中发挥重要作用.
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