在怀孕期间发展高血压是否会影响孕前的复发风险? 一个基于人口的队列研究
Inger Björk Ragnarsdóttir1, Tansim Akhter1, Katja Junus1
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
American journal of hypertension
|March 19, 2024
概括
妇女在他们的第一个怀孕和随后的怀孕期间高血压前在他们的第二个怀孕中面临着显著增加的早产前的风险,由于协同效应. 这凸显了在怀孕之间监测血压的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 怀孕期间的心血管健康
- 围产期流行病学 围产期流行病学
背景情况:
- 第一次怀孕时的孕前是一种已知的复发风险因素.
- 慢性高血压在怀孕之间发展 (怀孕间高血压) 对子宫前复发的影响尚未得到充分了解.
研究的目的:
- 调查第一次怀孕时产前和妊娠间高血压对第二次怀孕时产前风险的综合影响.
- 分析整体和早产前的复发风险.
主要方法:
- 基于人口的队列研究,对391,645名第一次和第二次单独分娩的妇女进行了研究 (2006-2017年).
- 分类暴露:第一次怀孕时的妊娠前,怀孕期间的高血压,两者,或没有.
- 在第二次怀孕中发生妊娠前复发的计算调整相对风险 (aRRs),包括早产和终产子组.
主要成果:
- 患有第一次怀孕前的女性在第二次怀孕中患有前的比例为21.5%,而没有怀孕期间高血压的女性为13.6%.
- 妊娠间高血压并没有显著改变第二次怀孕中总体妊娠前复发风险.
- 观察到第一次怀孕前和怀孕期间高血压之间的协同相互作用,用于早产前 (aRR 26.66).
结论:
- 患有先兆子史和随后的妊娠间高血压的妇女在第二次怀孕中显着增加了早产子的风险.
- 第一次怀孕时的先兆子和怀孕期间的高血压有协同作用,增加了早产前兆子的风险.
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