运动后血压与心血管结果和死亡率的关联:CARDIA研究
Jia-Jie Wang1,2, Zhichao Zheng2, Ying Zhang1,2
1The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
运动后的透气血压 (BP) 与重大心血管不良事件和死亡的风险更高有关. 这一发现在血压正常的个体中尤为明显,表明其预后价值.
科学领域:
- 心血管疾病流行病学
- 运动生理学 运动生理学
- 临床风险评估临床风险评估
背景情况:
- 办公室血压 (BP) 可能无法完全捕捉心血管风险.
- 运动后血压被认为是一种可能更敏感的预后标志物.
- 关于运动后BP对长期结果的预测价值的数据有限.
研究的目的:
- 调查运动后血压和主要不良心血管事件 (MACE) 之间的关联.
- 评估运动后血压与全因死亡率的关系.
- 为了确定运动后血压是否预测正常基线血压的个体的心血管风险.
主要方法:
- 从年轻成年人冠状动脉风险发展研究 (20年) 中对2581名参与者的分析.
- 包括接受了分级运动跑步机测试和基线运动后血压测量的参与者.
- 利用考克斯的比例危险模型来评估与MACE的关联性和所有原因的死亡率,平均随访时间为16年.
主要成果:
- 运动后的腹筋血压,但不是缩血压,与整体队列中MACE和全因死亡率的增加显著相关.
- 在基线血压正常的参与者中,运动后扩张性血压升高与MACE有很强的关联.
- 危险比率表明MACE风险增加27%,所有原因死亡风险增加26%,每增加10mmHg的运动后心压.
结论:
- 运动后的透气血压是主要心血管不良事件和全因死亡率的重要独立预测因素.
- 运动后的透静血压可以识别具有正常基线血压的个体,这些人患心血管事件的风险更高.
- 这些发现支持了运动后血压评估在心血管风险分层中的有用性.
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