淋巴细胞性淋巴瘤和多发性骨髓瘤在同一患者中共存:一个病例系列和文献综述
Gilad Itchaki1,2, Osnat Jarhovsky1,2, Jorge J Castillo3
1Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Leukemia & lymphoma
|March 19, 2024
概括
沃尔登斯特罗姆巨型球蛋白血症和多发性骨髓瘤可以同时发生,呈现出一种罕见的疾病.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 内部医学 内部医学
背景情况:
- 沃尔登斯特罗姆巨型球蛋白血症 (WM) 可能涉及血细胞克隆.
- 有症状的多发性骨髓瘤 (MM) 与性骨病变并发于WM是罕见的.
- 诊断和治疗这种WM-MM混合实体带来了重大挑战.
研究的目的:
- 描述WM和MM同时发生的患者的临床过程和治疗.
- 为了强调这种罕见的血液性恶性瘤组合的诊断挑战.
- 为了分享对这个"混合"实体的管理策略的见解.
主要方法:
- 追溯的案例系列.
- 多中心研究涉及以色列3个中心和美国2个中心.
- 临床表现,诊断工作和治疗干预措施的描述.
主要成果:
- 在五个中心确定了6名患有并发性WM和症状MM的患者.
- 在所介绍的病例中,临床过程和治疗方法各不相同.
- 该研究详细介绍了这些患者旅程的独特方面.
结论:
- 同时发生WM和症状MM是一种罕见但公认的临床实体.
- 诊断需要仔细评估,因为重叠的特征.
- 需要进行进一步的研究,以建立这种罕见的混合疾病的标准化治疗方案.
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