复星可以通过调节海马体中sirtuin 1相关途径来预防睡眠剥夺引起的认知缺陷
Yue-Ming Zhang1, Ru-Meng Wei1, Jing-Ya Zhang1
1Department of Neurology (Sleep Disorders), the Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000, Anhui, PR China.
Journal of biochemical and molecular toxicology
|March 19, 2024
概括
Resveratrol是一种Sirt1激动剂,通过减少炎症并通过Sirt1/miR-134通路改善突触功能来逆转睡眠剥夺引起的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 睡眠不足是认知障碍的重要危险因素,与炎症和突触功能障碍有关.
- Resveratrol是一种Sirt1激动剂,在各种神经疾病模型中显示出抗炎和神经保护作用.
- 对于睡眠剥夺引起的认知缺陷,Resveratrol对睡眠剥夺的好处的确切机制仍然在很大程度上是未知的.
研究的目的:
- 研究复星在缓解睡眠不足引起的认知缺陷方面的疗效.
- 阐明潜在的分子机制,重点关注Sirt1/miR-134通路和突触可塑性.
主要方法:
- 雄性C57BL/6J小鼠被分为对照组和睡眠剥夺 (SD) 组,有或没有白醇预治疗.
- 用莫里斯水迷宫测试来评估空间学习和记忆.
- 使用分子生物学技术分析了促炎性细胞因子和Sirt1/miR-134通路相关的蛋白质.
主要成果:
- 复星显著改善了睡眠剥夺引起的空间学习和记忆障碍.
- Resveratrol治疗降低了促炎性细胞因子 (IL-1β,IL-6,TNF-α) 的水平.
- 通过激活Sirt1/miR-134通路,复星增加了突触可塑性蛋白 (BDNF,TrkB,PSD-95,synaptophysin) 的水平.
结论:
- 复星在预防与睡眠剥夺相关的认知功能障碍方面表现出潜力.
- 保护作用通过减少促炎性细胞因子和通过Sirt1/miR-134通路增强突触功能来调解.
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