欧洲的牲畜具有很强的抵抗力
Patrick Munk1, Dongsheng Yang2, Timo Röder1
1National Food Institute, Technical University of Denmark, Lyngby, Denmark.
mSystems
|March 19, 2024
概括
甲基因组测序显示,牲畜中的抗菌素耐药性 (AMR) 是由抗菌素使用和细菌多样性驱动的. 生物安全措施对于控制欧洲各地在生产食品的动物中AMR的传播至关重要.
科学领域:
- 环境微生物学环境微生物学
- 兽医科学是一门兽医科学.
- 基因组学就是基因组学.
背景情况:
- 抗菌素耐药性 (AMR) 是一个重大的全球健康威胁.
- 在牲畜中监测抗菌素耐药性对于公共卫生和食品安全至关重要.
- 以前的研究主要集中在抗微生物药物使用 (AMU) 作为AMR的主要驱动因素.
研究的目的:
- 为了对五种欧洲生产食品的动物物种的抗体进行比较分析:猪,家禽,小牛,火和彩虹鱼.
- 研究农场管理实践和AMU对抗体组合的影响.
- 探索细菌多样性,抗菌体多样性,AMR丰富性以及细菌种群和抗菌素耐药性基因 (ARG) 的共同发生之间的关联.
主要方法:
- 来自九个欧洲国家的538个群体的抗体的比较基因组测序.
- 对管理实践的统计分析和AMU对猪,肉和小牛犊的抗体的影响.
- 网络分析用于研究细菌种群和ARG的共发生模式.
- 使用更新的数据库和生物信息学验证先前报告的关联.
主要成果:
- 根据动物类型 (猪/小牛犊,鸟类) 聚集的抵抗体,彩虹鱼是不同的.
- 确定了每个生产食品动物物种特有的核心抗体.
- 在细菌多样性和抗体多样性/丰富性之间发现了积极的关联.
- AMU被证实是关键驱动因素,但细菌多样性也与更高的AMR负载有关.
- 对ARG的分散限制显著影响了牲畜的抗体.
结论:
- 畜牧业的抗体是由AMU,细菌多样性和ARG分散限制所塑造的.
- 未来的抗菌耐药性控制战略必须将AMU的减少与细菌生态和生物安全的考虑相结合.
- 生物安全措施仍然是减轻牲畜群体中AMR传播的关键组成部分.
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