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全球类型3型型型流感病毒的家族遗传系动力学COVID-19流行后的全球类型3型型流感病毒

Kihyun Lee¹, Kuenyoul Park², Heungsup Sung³

¹CJ Bioscience, Seoul, South Korea.

|March 19, 2024

概括

第三种类型的偏流感病毒 (PIV-3) 遗传流行病学显示出流行病瓶效应. PIV-3可能起源于20世纪30年代,其复苏受到COVID-19措施的影响.

科学领域:

病毒学病毒学
流行病学流行病学
遗传学遗传学是一种遗传学.

背景情况:

在COVID-19大流行期间,由于控制措施,类型3 (PIV-3) 类型的偏流感病毒爆发率下降.
流行病后已经观察到PIV-3的复苏,但其遗传流行病学,包括潜在的瓶效应,仍然不清楚.

研究的目的:

调查过去65年PIV-3的遗传结构和遗传流行病学,包括COVID-19大流行时期.
探索遗传瓶效应对PIV-3复苏的潜在影响.
估计PIV-3的起源和进化史.

主要方法:

对PIV-3的455个全基因组和1139个血氨酸-神经氨基酶 (HN) 基因序列的家族遗传学分析.
使用贝叶斯天空网格凝聚的先验,构建最大概率的家族遗传树和时间尺度分析.
从NCBI获取的序列数据使用搜索术语"人类呼吸病毒3".

主要成果:

分析显示了PIV-3的10个全基因组和11个HN基因系,具有很高的竞争力.
在COVID-19大流行期间,PIV-3活动仅限于日本,韩国和美国的三个单一血统集群.
据估计,PIV-3的推断起源是在20世纪30年代 (1938年全基因组,1955年HN基因).

结论:

后COVID-19 PIV-3流行病很可能受到大流行驱动的瓶现象的影响.
这些发现支持以前的假设,即PIV-3起源于20世纪上半叶.
当全基因组数据有限时,HN基因是长期PIV-3流行病学研究的可行标记.

关键词:

在 COVID-19 疫情中,分子流行病学分子流行病学类似流感病毒的病毒.

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