在Magnaporthe oryzae中,MoMkk1和MoAtg1通过MoAtg9酸化对自和致病性进行二分法调节
Yun Kong1,2, Pusheng Guo1,2, Jiayun Xu1,2
1Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, and Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing, China.
这项研究揭示了两个蛋白质MoMkk1和MoAtg1如何对大米爆发真菌Magnaporthe oryzae的自产生相反的影响,影响其生长和感染植物的能力.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 菌类学 菌类学是指菌类学.
背景情况:
- 自是维持平衡和抗压力的关键细胞过程.
- 米爆真菌Magnaporthe oryzae依赖于宿主植物殖民的信号通路.
- 参与细胞壁完整性的激酶MoMkk1对于M. oryzae的自是必不可少的,但其调节机制尚不清楚.
研究的目的:
- 阐明MoMkk1调节Magnaporthe oryzae中的自的机制.
- 研究MoMkk1和MoAtg1在控制自和真菌致病性方面的相互作用.
主要方法:
- 研究了MoMkk1和MoAtg1.1对自蛋白MoAtg9的酸化情况.
- 评估了MoMkk1-和MoAtg1-依赖的MoAtg9酸化在自细胞形成中的作用.
- 评估了这些调节机制对大米真菌生长和病原性的影响.
主要成果:
- MoMkk1通过酸化MoAtg9来积极调节自,在自细胞形成过程中促进脂转位.
- MoAtg1通过MoAtg9酸化负面调节自,阻碍脂转位.
- 通过MoMkk1介导的酸化增强了真菌的毒性,而通过MoAtg1介导的酸化减弱了它.
结论:
- MoAtg9通过酸化受到MoMkk1和MoAtg1的二分法调节.
- 这项研究揭示了M. oryzae.中自和毒性调节的新机制.
- 在调节自中,MoMkk1和MoAtg1的对立作用对真菌发育和病原性至关重要.
更多相关视频
09:25Genome-wide Analysis of Histone Modifications Distribution using the Chromatin Immunoprecipitation Sequencing Method in Magnaporthe oryzae
Published on: June 2, 2021
06:51Analysis of Autophagy in Penicillium chrysogenum by Using Starvation Pads in Combination With Fluorescence Microscopy
Published on: February 1, 2015
相关概念视频
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway
Autophagy
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Phosphorylation
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
