在美国老年人中接种COVID-19双重疫苗后,中风风险较大
Yun Lu1, Kathryn Matuska2, Gita Nadimpalli2
1Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
JAMA
|March 19, 2024
概括
一项研究发现,在接受瑞-生物科技或莫德纳COVID-19双价疫苗后,老年人中风风险没有增加. 然而,当与流感疫苗同时使用时,发现了一些中风风险.
科学领域:
- 免疫学
- 流行病学
- 公共卫生
背景情况:
- 监管机构指出,在使用Pfizer-BioNTech双价COVID-19疫苗后,老年人中缺血性中风可能存在安全问题.
- 这促使对与COVID-19双价疫苗相关的潜在中风风险进行调查.
研究的目的:
- 评估COVID-19双价疫苗接种后发生中风的风险.
- 在同一天服用COVID-19双价和流感疫苗后评估中风风险.
- 单独接种流感疫苗后检查中风风险.
主要方法:
- 在65岁及以上的医疗保险受益者中进行了一项自我控制的病例系列研究.
- 这项研究包括2022年8月至2023年2月期间接种了超过530万名COVID-19双价疫苗的个人.
- 在接种疫苗后的1-21天和22-42天窗口内分析了中风事件,而对照窗口为43-90天.
主要成果:
- 在接受任何一种COVID-19双价疫苗后,没有观察到中风风险的统计显著增加.
- 在与流感疫苗同时使用时,发现了瑞- 生物科技双价疫苗与非出血性中风之间具有统计学意义的联系.
- 在与流感疫苗同时使用时,还发现了Moderna双价疫苗与过渡性缺血性发作之间的统计学意义上的关联.
结论:
- 该研究没有发现65岁以上的医疗保险受益者在接种COVID-19双价疫苗后风险增加的证据.
- 与高剂量或辅助性流感疫苗同时使用COVID-19双价疫苗显示出一些与中风结果的统计学意义上的关联.
- 这些发现表明,在老年人中,应仔细考虑联合使用的策略.
相关概念视频
01:51Vaccinations
44.5K
Overview
44.5K
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
00:42Cross-reactivity
31.1K
Overview
31.1K
01:17Transmission-based Precautions I: Contact, Enteric, and Droplets
3.6K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
3.6K
01:17Ischemic Heart Disease: Overview
1.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K
01:27Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30