治疗性阿菲雷斯:在患有脏疾病的儿童中是否安全?
Muhammed Doğukan Kalenderoğlu1, Elif Çomak2, Gülşah Kaya Aksoy2
1Department of Pediatrics, Faculty of Medicine, Akdeniz University, Antalya, Turkey. mdkalenderoglu@gmail.com.
Pediatric nephrology (Berlin, Germany)
|March 19, 2024
概括
儿科脏病患者的治疗性非 (TA) 通常是安全的,并发症仅发生在4.8%的会议中. 在这些治疗过程中观察到的最常见的不良事件是技术问题,例如血液流量不足.
科学领域:
- 儿科脏病学 儿科脏病学
- 医疗技术 医疗技术 医学技术
- 患者安全 患者安全
背景情况:
- 治疗性阿菲雷斯 (TA) 是儿童各种脏病的重要治疗方式.
- 了解TA在这个人群中的安全性概况对于优化患者护理至关重要.
- 这项研究解决了对小儿病中TA并发症的数据需求.
研究的目的:
- 确定患有脏疾病的儿童与治疗性非症相关的并发症的频率和类型.
- 为了确定特定的风险因素或患者群体,在TA期间出现不良事件的发病率较高.
主要方法:
- 对2007年至2022年期间接受TA的儿童 (≤18岁) 病历的回顾性审查.
- 排除具有不完整数据或非科诊断的患者.
- 分析了1214个TA疗程,包括治疗性血交换 (TPE) 和免疫吸附 (IA).
主要成果:
- 共有108名儿科患者接受了1214次TA治疗 (1147次TPE,67次IA).
- 在4.8%的疗程中出现并发症 (58/1214),4.6%的疗程由于不良事件而没有完成.
- 技术并发症 (41.4%),主要是流量不足,是最常见的,其次是过敏反应 (25.9%).
- 在3-6岁儿童中观察到更高的并发症率 (p=0.031).
结论:
- 在儿科脏病患者中,治疗性非与低的整体并发症率 (4.8%) 相关.
- 在这一群体中,技术问题是TA期间最常见的并发症.
- 年龄似乎是影响并发症发生率的一个因素,较年轻的儿童 (3-6岁) 经历的事件更多.
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