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Updated: Jun 30, 2025

Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy
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Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy

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通过3D囊泡探测球形纳米颗粒的包装动力学,使用基于力的模拟

Didarul Ahasan Redwan1, Ke Du2, Xin Yong1

  • 1Department of Mechanical Engineering, Binghamton University, Binghamton, New York 13902, USA. xyong@binghamton.edu.

Soft matter
|March 19, 2024
PubMed
概括

这项研究模拟了纳米粒子 - 囊泡相互作用,揭示了粒子位置和包裹如何影响细胞膜变形. 了解这些动态是评估纳米粒子安全性和生物影响的关键.

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Pinching-off of Coated Vesicles01:32

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Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
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