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在患有灌木伤寒的患者中,法典口激活:与器官功能障碍和不良结果相关

Jan K Damås^1,2,3, Kari Otterdal^4,3, Elisabeth Astrup^4,5,3

¹Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

|March 19, 2024

概括

擦伤风患者显示了Notch通路激活的增加,与与疾病严重程度和不良结果相关的Delta样蛋白1 (DLL1) 的升高. 这表明DLL1是灌木伤寒进展的潜在生物标志物.

科学领域:

* 传染病免疫学传染病免疫学
* 分子生物学 * 分子生物学
* 生物标志物发现发现

背景情况:

* 草伤寒引起的炎症的机制尚不清楚.
* 隙通路对于调节炎症和感染反应至关重要.
*诺奇信号在灌木伤寒中的作用以前没有被研究过.

研究的目的:

* 为了研究正统的Notch通路激活在灌木伤寒中的作用.
* 为了确定型蛋白1 (DLL1) 的血水平和型受体表达在草伤寒患者.
* 为了将Notch路径标记与疾病严重程度和患者结果相关联.

主要方法:

*酶免疫试验用于血DLL1水平.
*实时PCR用于全血中诺奇受体 (NOTCH1,NOTCH2,NOTCH4) RNA表达的实时PCR.
*研究包括来自南印度的草原伤寒患者 (n=129),发烧疾病对照组 (n=31) 和健康对照组 (n=31).

主要成果:

*显著增加的血DLL1和NOTCH4RNA表达的降低,在入院时观察到草伤寒患者.
* 在发烧性疾病对照组中观察到DLL1和NOTCH4变化的类似模式.
*高摄入血DLL1与疾病严重程度增加和短期存活率降低相关;体外数据表明感染单细胞中的Notch激活增强.

结论:

* 冲刷伤寒的特点是增强的正规的Notch路径激活.
*高血DLL1水平与器官功能障碍和草伤寒患者的不良结果有关.
*DLL1可能作为灌木伤寒的潜在预后生物标志物.

关键词:

东方的 tsutsugamushi 东方的 tsutsugamushi 是一个类似三角洲的11 炎症炎症是一种炎症.口信号传输是没有的.擦洗伤寒病毒的伤寒.

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