莱沃多巴减轻了牛中草类化合物引起的料摄入量减少
Eriton E L Valente1, James L Klotz2, Ryana C Markmann1
1Animal Science Department, State University of Western Parana, Marechal Cândido Rondon, PR, Brazil.
Journal of animal science
|March 19, 2024
概括
莱沃多巴 (L-DOPA) 补充剂部分减轻了牛群中受感染的高的藻类的负面影响. L-DOPA改善了干物质的摄入和葡萄糖的新陈代谢,为毒症提供了潜在的治疗方法.
科学领域:
- 动物科学动物科学
- 类动物营养 类动物营养
- 毒理学 毒理学 毒理学
背景情况:
- 来自受内菌感染的高体的藻类导致畜牧业的重大损失.
- 需要有效的缓解策略来应对毒性.
- 多巴胺代谢与藻类的生理效应有关.
研究的目的:
- 为了评估内腹内多巴 (L-DOPA) 输注在暴露于草类化合物的牛群中的疗效.
- 评估L-DOPA对多巴胺代谢,料摄入量和血清代谢物的影响.
- 为了确定L-DOPA是否可以减轻体毒性病的不良影响.
主要方法:
- 十二只荷尔斯坦牛被养了具有内菌感染 (E+) 或无内菌 (E-) 的高菌种子.
- 马匹接受了水或勒沃多巴 (L-DOPA) 的腹腔内注射.
- 在热挑战条件下测量了料摄入量,血清代谢物和葡萄糖耐受性.
主要成果:
- 被内菌感染的高 (E+) 减少了益生素和干物质摄入量 (DMI),但L-DOPA部分扭转了这些效应.
- 输入L-DOPA增加了食用E+的牛的多巴胺水平和进食时间.
- 随着L-DOPA+的使用,葡萄糖清除率显著改善,独立于E+暴露.
结论:
- 列沃多巴 (L-DOPA) 显示出作为一种激动剂疗法的潜力,以抵消体毒性.
- 补充L-DOPA适度增加了受影响的牛的DMI和进食时间.
- L-DOPA增强了血葡萄糖清除,表明改善了代谢功能.
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