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Updated: Aug 17, 2026

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建立一种致命的小鼠模型,用于新出现的传播的ortonairovirus感染

Takuma Ariizumi1, Koshiro Tabata2, Yukari Itakura2

  • 1Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.

PLoS pathogens
|March 19, 2024
PubMed
概括

一种使用AG129小鼠的新型小鼠模型有效地模仿了叶索病毒 (YEZV) 感染,有助于对传播的ortonairoviruses的研究,并测试像favipiravir.vir这样的抗病毒药物.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...