卡拉基南薄膜作为有前途的粘膜粘合眼部药物递送系统
Aleksandra V Volod'ko1, Elvira Yu Son1, Valery P Glazunov1
1G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 100 Let Vladivostoku Prosp., 159, Vladivostok 690022, Russia.
Colloids and surfaces. B, Biointerfaces
|March 19, 2024
概括
载有赤色 (ECH) 的卡拉基南 (CRG) 薄膜对眼科药物输送有前途,提供粘膜粘合和稳定性. 这些新的膜增强了药物保留力,没有细胞毒性,是传统眼滴的可行替代品.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 眼科药物输送面临着传统剂量形式的挑战,包括通过眼快速清除.
- 粘粘性聚合物,如卡拉基南 (CRGs),有可能在眼睛中延长药物接触时间.
- 卡拉基南 (CRG) 存在于各种结构类型 (例如, κ/β, κ, x, λ) 影响其特性.
研究的目的:
- 开发和描述用于眼科药物输送的粘粘性卡拉基 (CRG) 薄膜.
- 为了评估色 (ECH) 装载的CRG薄膜的稳定性,粘粘度,胀和药物释放.
- 评估CRG/ECH膜在眼睛细胞系上的安全性.
主要方法:
- 准备具有不同CRG结构 (κ/β, κ, x, λ) 的CRG片,并加载 echinochrome (ECH).
- 使用光谱数据评估ECH稳定性.
- 在人造眼中,膜胀,粘膜凝结 (使用纹理分析仪和猪小肠模型) 和人工眼的风湿性质的表征.
- 在人角膜和结膜上皮细胞的体外细胞毒性测试.
主要成果:
- 在CRG薄膜中, Echinochrome (ECH) 至少保持六个月的稳定性和无氧化.
- 根据CRG结构,CRG膜表现出不同的胀行为;高硫酸CRG溶解,而低硫酸 κ/β-CRG显示出有限的胀.
- 所有装有ECH的CRG薄膜都显示出粘膜粘合性和人工眼中ECH释放的轻微延长.
- 带有ECH的 κ-和 κ/β-CRG膜在补水后表现出伪塑性行为.
- 在低度下,CRG/ECH复合体对眼睛上皮细胞没有细胞毒性作用.
结论:
- 卡拉基南 (CRG) 带有色 (ECH) 的薄膜是一种稳定和粘膜系统,用于眼科药物输送.
- CRG结构影响膜膨胀和溶解,为药物释放提供可调节的特性.
- 这些CRG/ECH膜增强药物保留力,对眼部组织是安全的,为传统眼滴提供了有希望的替代品.
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