获得的囊性疾病相关的细胞癌:系统性审查和元分析
Nguyen Xuong Duong1, Minh-Khang Le2, Tuan Thanh Nguyen3
1Department of Urology, University of Yamanashi Graduate School of Medical Sciences, Chuo-city, Japan; Department of Urology, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
Clinical genitourinary cancer
|March 19, 2024
概括
在透析患者中,获得的囊性疾病相关细胞癌 (ACD-RCC) 呈现出明显的特征. 这种亚型具有更长的透析持续时间和独特的基因突变,如KMT2C和TSC2.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 获得的囊性疾病相关细胞癌 (ACD-RCC) 在末期病 (ESRD) 患者中很普遍.
- 了解ACD-RCC独特的临床病理和遗传特征对于患者管理至关重要.
研究的目的:
- 系统地审查和元分析ACD-RCC的临床病理和遗传特征.
- 为了比较ACD-RCC与透明细胞RCC (ccRCC) 和乳头细胞RCC (pRCC).
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行系统的文献搜索,直到2022年12月31日.
- 根据PRISMA 2020指南进行的元分析.
- 分析了26篇文章,包括2199名患者和2314名瘤 (418名ACD-RCC).
主要成果:
- ACD-RCC患者主要是男性 (80.2%),平均透析持续时间为148.2个月.
- 与ccRCC和pRCC相比,ACD-RCC显示透析持续时间更长,多焦点瘤的发病率更高.
- 常见的遗传异常包括染色体3和16,观察到KMT2C和TSC2突变.
结论:
- 与其他RCC亚型相比,ACD-RCC具有明显的临床病理和遗传特征.
- 进一步的研究是有必要的,以充分阐明ACD-RCC生存结果和遗传景观.
相关概念视频
01:28Urinary Tract Calculi I: Introduction
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...