胃食道腺癌与缺陷不匹配修复:当前知识和临床管理

Matthew R Strickland1, Eric M Lander2, Michael K Gibson2

  • 11Division of Hematology-Oncology, Department of Medicine, Massachusetts General Cancer Center, Boston, MA.

概括

检测不匹配修复缺陷/微卫星不稳定性 (dMMR/MSI-H) 对所有胃食道腺癌患者至关重要. 这种生物标志物确定了一个从免疫检查点抑制剂中显著受益的子组,可能避免化疗.

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