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Updated: Jun 30, 2025

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具有银和氧化释放能力的生物灵感超表面可以防止与设备相关的感染和血栓形成

Ekrem Ozkan¹, Lori M Estes Bright¹, Anil Kumar¹

¹School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.

Journal of colloid and interface science

|March 19, 2024

概括

这项研究开发了一种新型的超水表面,释放氧化 (NO),用于对抗医疗器械上的感染和血栓形成. 创新的SH-SiAgNO材料显著减少了细菌和血小板,没有毒性,为与设备相关的并发症提供了一个新的策略.

科学领域:

生物材料科学生物材料科学
表面化学表面化学
医疗设备工程医疗设备工程

背景情况:

接触血液的医疗器械面临来自细菌相关感染和血栓形成的并发症.
目前的策略包括表面功能化和抗污染药物输送.
(SR) 被广泛使用,但易受生物膜和血栓形成的影响.

研究的目的:

开发一种新型的功能性聚合物材料,集成超性和氧化 (NO) 释放.
为医疗器械创建具有联合抗血栓和抗微生物特性的表面.
评估开发的表面对细菌粘附和血小板聚合的有效性和安全性.

主要方法:

用化二氧化 (SiO2) 和银 (Ag) 纳米粒子 (NP) 涂抹医用级 (SR),使用粘合性聚合物粘合剂.
用S-nitroso-N-乙烯基胺 (SNAP) 浸超性 (SH) SR基底,一个NO供体,以创建SH-SiAgNO表面.
与对照组相比,评估SH-SiAgNO表面的细菌减少 (大肠杆菌,金黄色细菌) 和血小板粘附.
评估SH-SiAgNO表面对纤维细胞的细胞毒性影响.

主要成果:

在SH-SiAgNO表面,可活的粘附大肠杆菌 (> 99.9%) 和黄金色大肠杆菌 (> 99.8%) 显著减少.
与对照表面相比,SH-SiAgNO表面的血小板粘附率大幅降低 (> 96.1%).
开发的表面没有对纤维细胞细胞毒性影响,表明良好的生物相容性.
结合的超性和NO释放性质有效地防止了生物污染,细菌粘附和血栓形成.

结论:

新的SH-SiAgNO表面有效地将生物启发的超性与氧化释放相结合.
这种方法为医疗器械提供了强大的抗微生物和抗血栓性质.
开发的材料为传统的全身抗凝药和抗生素治疗提供了一个有希望的替代方案,以尽量减少与设备相关的并发症.

关键词:

防的方法是防.抗微生物药物抗微生物药物氧化氧化是什么?银银银银银银银超水性超水性血栓形成的原因之一是血栓形成.

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