ITNR:基于倒置变压器的神经排名用于癌症药物推
Shahabeddin Sotudian1, Ioannis Ch Paschalidis2
1Department of Electrical and Computer Engineering, Division of Systems Engineering, Boston University, Boston, MA, USA.
Computers in biology and medicine
|March 19, 2024
概括
本研究引入了一种基于倒置变压器的神经排名 (ITNR) 模型,用于个性化药物反应预测. ITNR有效地捕捉了药物-细胞系关系,在预测患者特异性治疗策略方面优于现有方法.
科学领域:
- 计算生物学是一种计算生物学.
- 基因组学就是基因组学.
- 机器学习是机器学习.
背景情况:
- 个性化药物反应预测定制使用瘤基因组数据的治疗方法.
- 目前的机器学习模型在各种细胞系中与药物-细胞系关系复杂性作斗争.
研究的目的:
- 引入一个新的列表式学习到等级 (LTR) 模型,基于倒置变压器的神经排名 (ITNR).
- 通过利用基因组特征和变压器架构来增强对患者特定药物反应的预测.
主要方法:
- 开发了一种名单式的新型学习到等级 (LTR) 模型,称为基于倒置变压器的神经排名 (ITNR).
- 在ITNR模型中利用了基因组特征和变压器架构.
- 在三个主要的药物反应数据集上进行ITNR培训和评估.
主要成果:
- ITNR在预测药物反应方面表现出卓越的表现.
- 该车型的性能始终优于现有的最先进的LTR车型.
- ITNR有效地破译了药物和细胞系之间的功能关系.
结论:
- ITNR提供了一个强大的方法来预测个性化药物反应.
- 该模型捕捉复杂药物细胞系相互作用的能力改善了治疗策略的量身定制.
- ITNR代表了将机器学习应用于精密瘤学的重大进步.
更多相关视频
04:09Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
Published on: October 10, 2018
8.2K
09:53Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
Published on: August 16, 2020
7.2K
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K