人类恶性瘤中的c-MET通路及其向性由天然化合物用于癌症治疗
Chakrabhavi Dhananjaya Mohan1, Muthu K Shanmugam2, Siddegowda Gopalapura Shivanne Gowda3
1FEST Division, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh 226 001, India.
概括
该c-MET途径驱动癌症的生长和抵抗. 自然化合物在抑制c-MET信号传递方面表现有前途,为各种癌症提供新的治疗策略,包括骨转移.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由HGF激活的c-MET通路调节了重要的细胞过程,如增殖,血管生成和EMT.
- 通过过度表达或突变,c-MET信号的放松调节与许多癌症有关,与糟糕的结果和治疗耐药性相关.
- 针对c-MET途径是癌症治疗中的关键策略,因为它在瘤发生过程中的作用.
研究的目的:
- 分析c-MET途径在人类癌症中的作用.
- 调查c-MET在骨转移和治疗耐药性的参与.
- 总结自然化合物对癌症中c-MET信号传递的抑制作用.
主要方法:
- 在PubMed,Scopus和Google Scholar上进行文献搜索,使用"c-MET"",天然化合物抑制剂"和特定癌症类型等关键词.
- 根据PRISMA指导方针,总结了出版物.
- 使用PubChem数据库验证了天然化合物的化学结构.
主要成果:
- 从3935.5的初始搜索中分析了195个选定的出版物.
- 该c-MET途径是抑制癌症生长,转移和化学抵抗的重要目标.
- 选择的天然化合物在临床前和临床研究中证明了对c-MET信号的抑制作用.
结论:
- 在瘤学中,c-MET途径是关键的点,特别是在克服骨转移和治疗抵抗方面.
- 自然化合物代表了开发新型c-MET抑制剂的有希望的途径.
- 为了改善癌症治疗,需要对包括天然化合物在内的c-MET向疗法的进一步研究.
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